Genetic Disorders

What is the genetic mutation responsible for lethal white syndrome?

Lethal white syndrome is a genetic disorder primarily affecting horses, particularly those with overo coat patterns. It is caused by a mutation in the Endothelin receptor type B (EDNRB) gene, which leads to the absence of nerve cells in the intestines, resulting in fatal complications shortly after birth. What Causes Lethal White Syndrome? Lethal white […]

4 min read
Genetic Disorders

Is lethal white syndrome hereditary?

Lethal white syndrome, or overo lethal white syndrome (OLWS), is a hereditary genetic disorder affecting foals. It is primarily found in horses with certain coat patterns, particularly those with overo paint patterns. This condition is caused by a genetic mutation and is not curable, leading to severe health issues shortly after birth. What is Lethal […]

3 min read
Genetic Disorders

What is the lethal white syndrome related to overo horses?

Lethal white syndrome in overo horses, also known as overo lethal white syndrome (OLWS), is a genetic disorder that affects foals born with certain coat patterns. These foals appear healthy at birth but suffer from a non-functioning colon, leading to severe colic and death within a few days. Understanding this condition is crucial for breeders […]

3 min read