Genetic Disorders What is the genetic mutation responsible for lethal white syndrome? February 9, 2026 by Riding Lethal white syndrome is a genetic disorder primarily affecting horses, particularly those with overo coat patterns. It is caused by a mutation in the Endothelin receptor type B (EDNRB) gene, which leads to the absence of nerve cells in the intestines, resulting in fatal complications shortly after birth. What Causes Lethal White Syndrome? Lethal white […] Read more »
Genetic Disorders Is lethal white syndrome hereditary? February 9, 2026 by Riding Lethal white syndrome, or overo lethal white syndrome (OLWS), is a hereditary genetic disorder affecting foals. It is primarily found in horses with certain coat patterns, particularly those with overo paint patterns. This condition is caused by a genetic mutation and is not curable, leading to severe health issues shortly after birth. What is Lethal […] Read more »
Genetic Disorders What is the lethal white syndrome related to overo horses? February 9, 2026 by Riding Lethal white syndrome in overo horses, also known as overo lethal white syndrome (OLWS), is a genetic disorder that affects foals born with certain coat patterns. These foals appear healthy at birth but suffer from a non-functioning colon, leading to severe colic and death within a few days. Understanding this condition is crucial for breeders […] Read more »