Equine Veterinary Science What is the role of chloride in a horse’s nervous system? February 5, 2026 by Riding Chloride ions (Cl⁻) play a vital role in a horse’s nervous system, primarily in maintaining electrical neutrality and osmotic balance in extracellular fluids. They contribute to the membrane potential of neurons, which is essential for nerve signal transmission. While changes in chloride concentration have less impact on the membrane potential compared to potassium and sodium, […] Read more »